Discrepancies in International Normalized Ratio Results between Instruments: A Model to Split the Variation into Subcomponents
نویسندگان
چکیده
منابع مشابه
Discrepancies in international normalized ratio results between instruments: a model to split the variation into subcomponents.
BACKGROUND Observed differences between results obtained from comparison of instruments used to measure international normalized ratio (INR) have been higher than expected from the imprecision of the instruments. In this study the variation of these differences was divided into subcomponents, and each of the subcomponents was estimated. METHODS Blood samples were collected at 4 different pati...
متن کاملInternational Normalized Ratio ( Inr )
Prothrombin time can be measured roughly on whole blood as in neonates, but is more commonly measured from plasma. Blood is taken into a vacutainer containing liquid citrate. Citrate acts as an anticoagulant by consuming all the calcium in the sample. The blood is mixed and centrifuged to separate blood cells from the plasma. The plasma is placed in a coagulation machine which takes a sample of...
متن کاملInternational normalized ratio.
Dear Madam, The P.T. assay, first described in 1935 by Quick et al. soon became the monitoring of oral anticoagulant therapy. The P.T. measures the affect of reduction in the Vit. K dependent coagulant factors II, VII and X. Because the Prothrombin Time Ratio (P.T.R.) is markedly affected by the activity of thromboplastin, the W. It helps to determine the intensity of anti-coagulation therapy b...
متن کاملTherapeutic International Normalized Ratio Monitoring
studies have shown that the percentage of ring sideroblasts in MDS is not prognostically important. Thus, in the revised WHO classification, a diagnosis of MDS-RS may be made even in the presence of only 5% of ring sideroblasts in cases with SF3B1 mutation. MDS-RS cases will be subdivided into cases with single lineage dysplasia (previously classified as RARS) and cases with multilineage dyspla...
متن کاملProblems with the international normalized ratio.
In a recent letter to Blood, Hirsh called attention to the inadequacy of monitoring warfarin dosage by the prothrombin time assay (PT) as commonly performed in the United States.’ The actual PT value may vary widely from laboratory to laboratory because the result is dependent on the “responsiveness” of the thromboplastin used for the test, and because the thromboplastin reagents distributed co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2010
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2010.146233